MECHANISM OF ACTION : Follitropin beta is a recombinant form of endogenous follicle stimulating hormone .FSH binds to follicle stimulating hormone receptor which is a
G- coupled transmembrane receptor. The binding induces phosphrylation and activation of PI3K and Akt signaling pathway ,which is known to regulate many other metabolic and related
survival ?maturation function in cells.
PHARMACOLOGICAL ACTION: Used for the treatment of female infertility . Follitropin beta stimulates ovarian follicular growth in women who donot have primary ovarian failure.
THERAPEUTIC USES:
1 .AMENORRHOEA : When it is due to deficient production of gns by pituitary .They are usually tried when attempts to induce ovulation with clomipene have failed.
2 .HYPOGONADOTROPIN HYPOGONADISM IN MALES : Sexual maturation is induced by androgens and therapy with HCG is started when fertility is desired.
3. CRYPTORCHIDISM : Since undescended testes can cause infertility and predispose to testicular cancer is imperative.
ADVERSE EFFECTS :
1. Ovarian hyperstimulation
2. Allergic reaction
3. Edema, headache, mood changes.
REFERENCE- Tripathi K.D. "Essentials of Medical Pharmacology", 7th Edition, page no- 241
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