SULFADIAZINE -SPECIAL PURPOSE SULFONAMIDES AND IT'S SIDE EFFECTS

INTRODUCTION

One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infection.

 THERAPEUTIC USES

• In urinary tract infection
• Burns
• Toxoplasmosis

SIDE EFFECT

• Anxiety
• Blurred vision
• Coma
• Decrease sexual ability in males
• Depression
• Dizziness
• Fast heartbeat
• Feeling cold

MECHANISM OF ACTION

Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteoate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

DRUG-DRUG INTERACTION

Sulfadiazine+Alogliptin= It may increase the hypoglycemic activities of    

                                               Sulfadiazine.

Sulfadiazine+Bosentan= The serum concentration of bosentan can be increased

                                               When it is combined with sulfadiazine.

Sulfadiazine+Carvedilol= The serum concentration of carvedilol can be increased

                                                 When it is combined with sulfadiazine.            

REFERENCE

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.704-705