SULFACETAMIDE - SPECIAL PURPOSE SULFONAMIDE AND ITS SIDE EFFECTS

Introduction

An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infection.

  THERAPEUTIC USES

• Treating eye infection caused by certain bacteria
• Acne
• Seborrheic dermatitis

SIDE EFFECT

• Local/conjuctival irritation
• Stinging
• Burning
• Fungal corneal ulcers
• conjuctival hyperemia

PHARMACOKINETICS

Biological half-life                 7 to 12.8 hour

MECHANISM OF ACTION

Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), an essential component for bacterial growth. The inhibited reaction is necessary in these organisms for synthesis of folic acid.

Side effect

Sulfacetamide+Mecamylamine= The risk or severity of adverse effects can be 

                                                             Increased when sulfacetamide is combined 

                                                              With mecamylamine.

REFERENCE

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.704-705