FOSFESTROL- Anti-Cancer drug

                                               

DESCRIPTION-

Fosfestrol (INN, BAN, JAN) (brand names Honvan, Difostilben, Fosfostilben, Fostrolin, Stilbol, Stilphostrol, Vagestrol, among others), also known as diethylstilbestrol diphosphate (DESDP, DESP), is a synthetic, non-steroidal estrogen of the stilbestrol group that is used in the treatment of prostate cancer.

MECHANISM OF ACTION-

Fosfestrol competitively binds to the androgen receptors present on the prostate gland and form a drug-receptor complex. This inhibits the action of androgen on prostate gland and also hormone induced growth of cancer cell.

USES-

  *  Breast Cancer

  * Dermatomyositis,

  *Nasopharyngeal Fibromas

  *Oncology

  *Parathyroid Carcinoma

  *Plasmacytomas

  *Prostatic Cancer,

  *Rheumatoid Arthritis.

DOSAGE-

Composition:

Medicine

Fosfestrol(120 mg)

Honvan (120mg) , Honvan Tab

Fosfestrol(60 mg)

Honvan Mt(300mg) , Honvan (300mg)

Fosfestrol(300 mg)

Honvan .(5ml)

CONTRAINDICATION-

*Hypertension

*Cardiac failure

*Liver diseases

*Cerebrovascular disease.

SIDE EFFECT-

*Congestive heart failure

*Dizziness,

* Anorexia

*Diarrhea

* Fever

* Nausea

* Vomiting

*Perineal Pruritis

REFERENCE-

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no- 308,872.