Wednesday, February 21, 2018

PHENCYCLIDINE - ARYLCYCLOHEXYL AMINES :ITS SIDE EFFECTS AND USES

INTRODUCTION-

Phencyclidine (PCP), also known as angel dust and Sernyl among others, is a dissociative drug. PCP was brought to market in the 1950s as an anesthetic pharmaceutical drug but was taken off the market in 1965 due to the high prevalence of dissociative hallucinogenic side effects. PCP is a member of the arylcyclohexylamine class, and, in pharmacology, it is a member of the family of dissociative anesthetics. PCP works primarily as an NMDA receptor antagonist, where it blocks the activity of the NMDA receptor. As an addictive drug, PCP is associated with compulsive abuse

MECHANISM OF ACTION-

The N-methyl-D-Aspartate (NMDA) receptor, a type of ionotropic receptor, is found on the dendrites of neurons and receives signals in the form of neurotransmitters. It is a major excitatory receptor in the brain. Normal physiological function requires that the activated receptor fluxes positive ions through the channel part of the receptor. PCP enters the ion channel from the outside of the neuron and binds, reversibly, to a site in the channel pore, blocking the flux of positive ions into the cell. PCP therefore inhibits depolarization of neurons and interferes with cognitive and other functions of the nervous system

USES-

Used as a pesticide and a disinfectant.

SIDE EFFECTS-

1-Unsteady gait
2-Slurred speech
3-Bloodshot eyes
4-Loss of balance

REFERENCE-

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.452                                                                 
                                                                 

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