Mecamylamine- drugs acting on autonomic ganglia

                                                                                                                                                                                                                                 MECAMYLAMINE
MECHANISM OF ACTION –
 mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by Ach released from presynaptic nerve endings. The hypotensive effect of mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is  primarily postural.

PHARMACOLOGICAL ACTION –
Mecamylamine is a potent, oral antihypertensive agent and ganglionic blocker, and is a secondary amine.
It reduces blood pressure in both hypotensive and hypertensive individuals.
It crosses the blood-brain and placental barriers.

USES –
1. Mecamylamine is used to treat moderately severe to severe  high BP.
2. It can also be used in malignant hypertension.
3. Lowering high BP helps prevent strokes, heart attacks, and kidney problems.

SIDE EFFECTS –
Drowsiness
Dizziness
Tiredness
Blurred vision
Decreased sexual ability/interest
Nausea
Constipation
Dry mouth



DRUG-DRUG INTERACTION –
Mecamylamine + Acetazolamide = the risk or severity of adverse effects can be increased.
Mecamylamine + Amikacin = Amikacin may increase the neuromuscular blocking activities of Mecamylamine.
Mecamylamine + Bumetadine = the risk or severity of adverse effects can be increased.

Reference- Tripathi KD," Essentials of Medical Pharmacology", 7th edition,page no- 123.