Magaldrate -drug for peptic-ulcer

                                                                                                                                                        MAGALDRATE

MECHANISM OF ACTION-

 Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly in gastric acid to Mg (OH)2 and Al(OH)3 , which are absorbed poorly and thus provide a sustained effect.

USES- 

1. Ulcer

2. GERD

3. Dyspepsia

4. Heart burn

SIDE EFFECTS-

1. Increase HCl production and Gastrin

2. Acid rebound

3. Mild constipation

PHARMACOLOGICAL ACTION- 

1. Gastric secretion

2. H 2 blockade

DRUG- DRUG INTERACTION-

Magaldrate + Ketoconazole = decrease absorption of Magaldrate

Magaldrate + Diazepam = decrease absorption of Magaldrate

Magaldrate + Phenytoin = decrease absorption of Magaldrate

Magaldrate + H2 blocker = decrease absorption of Magaldrate 

Magaldrate + Isoniazid = decrease absorption of Magaldrate

Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 655