SULFSALAZINE DISEASE MODIFYING ANTI RHEUMATIC DRUG, DRUG FOR INFLAMMATORY BOWEL DISEASE, SPECIAL PURPOSE SULFONAMIDE AND IT'S PHARMACOLOGY

INTRODUCTION

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid released in the colon.

 THERAPEUTIC USES

• To reduce inflammation and pain in rheumatism arthritis.
• Juvenile rheumatoid arthritis.
• Ulcerative colitis.

SIDE EFFECT

• Aching of joints
• Increased sensitivity of the skin to sunlight
• Fever
• Dark urine
• Bleeding gums
• Fast heartbeat
• Chest pain
• Bloody diarrhea

PHARMACOKINETICS

Bioavailability                                 <15%

Biological half-life                          5-10 hours

  

MECHANISM OF ACTION

In ulcerative colitis, clinical studies utilizing rectal administration of Sulfasalazine, SP and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety.

DRUG-DRUG INTERACTION

Sulfasalazine+Follic acid= The serum concentration of folic acid can be 

                                                 Decreased when it is combined with sulfasalazine.

Sulfasalazine+Mecamylamine= The risk of severity of adverse effects can be 

                                                      Increased when it is combine with mecamylamine.

Sulfasalazine+Methotrexate= It may increase the hepatotoxic activities of

                                                        Methotrexate.

REFERENCE

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.210-211,683-684,706