Miconazole- Antifungal drug

MICONAZOLE:
• It is an imidazole antifungal agent.
• Commonly applied topically to the skin or to mucous membrane to cure fungal infection.

PHARMACOKINETICS:
• Metabolism is through liver.
• Excreted unchanged through urine.

THERAPEUTIC USES:
• It is used in various skin infection which includes:
a) Athlete’s foot.
b) Jock itch.
c) Ring worm.
• Pityriasis.
• Mouth thrush.
• Tinea versicolor.

ADVERSE EFFECTS:
• Phlebitis at infusion site.
• Pruritis.
• Rash.
• Skin irritation.
• Sensitization.
• Burning.
• Arrhythmia.
• Tachycardia.
• Chills.
• Fever.
• Anorexia

DRUG-DRUG INTERACTION:
• MICONAZOLE + WARFARIN = increased anticoagulant effect of Warfarin hence increased bleeding.
• MICONAZOLE + HYDANTOIN = Decreased metabolism of Hydantoin hence increase in toxicity.
• MICONAZOLE + AMPHOTERICIN B = Decreased effect of Amphotericin B.

Reference-Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no-787,792