PHYSOSTIGMINE-
INTRODUCTION
Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. Physostigmine is used to treat glaucoma. Because it crosses the blood-brain barrier, it is also used to treat the central nervous system effects of atropine overdose and other anticholinergic drug overdoses. Physostigmine can reverse both central and peripheral anticholinergia
MECHANISM OF ACTION
Physostigmine inhibits acetylcholinesterase, the enzyme responsible for the breakdown of used acetylcholine. By interfering with the metabolism of acetylcholine, physostigmine indirectly stimulates both nicotinic and muscarinic receptors due to the consequential increase in available acetylcholine at the synapse.
USES
used to treat glaucoma and delayed gastric emptying
used to treat anticholinergic poisoning .
used to reverse neuromuscular blocking.
SIDE EFFECT
overdose can cause cholinergic syndrome
nausea,
vomiting,
diarrhea,
anorexia,
dizziness,
headache,
stomach pain,
sweating,
dyspepsia,
seizures
DRUG INTERACTION
Acetylcholine
The risk or severity of adverse effects can be increased when Physostigmine is combined with Acetylcholine.
Atracurium besylate
Physostigmine may decrease the neuromuscular blocking activities of Atracurium besylate.
Carbachol
The risk or severity of adverse effects can be increased when Physostigmine is combined with Carbachol.
Dipyridamole
The therapeutic efficacy of Physostigmine can be decreased when used in combination with Dipyridamole.
Fludrocortisone
The risk or severity of adverse effects can be increased when Fludrocortisone is combined with Physostigmine.
Nadolol
Physostigmine may increase the bradycardic activities of Nadolol.
Procyclidine
The therapeutic efficacy of Procyclidine can be decreased when used in combination with Physostigmine.
Succinylchol
The serum concentration of Succinylcholine can be increased when it is combined with Physostigmine.
REFERENCE-
ESSENTIAL OF MEDICAL PHARMACOLOGY BY K.D TRIPATHI7th edition pg.no.105-110
INTRODUCTION
Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. Physostigmine is used to treat glaucoma. Because it crosses the blood-brain barrier, it is also used to treat the central nervous system effects of atropine overdose and other anticholinergic drug overdoses. Physostigmine can reverse both central and peripheral anticholinergia
MECHANISM OF ACTION
Physostigmine inhibits acetylcholinesterase, the enzyme responsible for the breakdown of used acetylcholine. By interfering with the metabolism of acetylcholine, physostigmine indirectly stimulates both nicotinic and muscarinic receptors due to the consequential increase in available acetylcholine at the synapse.
USES
used to treat glaucoma and delayed gastric emptying
used to treat anticholinergic poisoning .
used to reverse neuromuscular blocking.
SIDE EFFECT
overdose can cause cholinergic syndrome
nausea,
vomiting,
diarrhea,
anorexia,
dizziness,
headache,
stomach pain,
sweating,
dyspepsia,
seizures
DRUG INTERACTION
Acetylcholine
The risk or severity of adverse effects can be increased when Physostigmine is combined with Acetylcholine.
Atracurium besylate
Physostigmine may decrease the neuromuscular blocking activities of Atracurium besylate.
Carbachol
The risk or severity of adverse effects can be increased when Physostigmine is combined with Carbachol.
Dipyridamole
The therapeutic efficacy of Physostigmine can be decreased when used in combination with Dipyridamole.
Fludrocortisone
The risk or severity of adverse effects can be increased when Fludrocortisone is combined with Physostigmine.
Nadolol
Physostigmine may increase the bradycardic activities of Nadolol.
Procyclidine
The therapeutic efficacy of Procyclidine can be decreased when used in combination with Physostigmine.
Succinylchol
The serum concentration of Succinylcholine can be increased when it is combined with Physostigmine.
REFERENCE-
ESSENTIAL OF MEDICAL PHARMACOLOGY BY K.D TRIPATHI7th edition pg.no.105-110
No comments:
Post a Comment