MECHANISM OF ACTION
Minoxidil is thought to promote the survival of human dermal papillary cells or hair cells by acting both extracellular signal regulated kinase and Akt and by preventing cell death by increasing the ratio of BCI-2/Bax. MINOXIDIL may stimulate the growth of human hair by prolonging anagen through these proliferating and anti apoptotic effects on DPCs. Minoxidil when use as a vasodilator act by opening adenosine triphosphate sensitive K channels in vascular smooth muscle cells. This vasodilation may also improve the viability of hair cells or hair follicles.
USES
- Antihypertensive agent
- Vasodilator agent
- Dermatologicals
- Cardiovascular system
- Pyrimidine derivative
SIDE EFFECTS
- Acne at site of application
- Burning of scalp
- Chest pain
- Dizziness
- Fainting
- Irregular heartbeat
- Headache
- Flushing
- Weight gain (rapid)
DRUD DRUG INTERACTION
1. Alfuzosine + minoxidil = may increase the hypotensive activity of minoxodil
2. Amifostin + minoxidil = minoxidil may increase the hypotensive activity of amifostin
3. Dapoxetin+minoxidil = dapoxetin may increase orthostatic hypotensive activity of minoxidil
4. Cyclosporin + minoxidil = the risk or severity of adverse effects can be increased when cylco- sporine id combined with minoxidil.
5. Butethal + minoxidil = increase the hypotensive activity of minoxidil.
REFERENCE
Tripathi K.D. "Essentials of Medical Pharmacology", 7th Edition, page no.552,567.
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