PRAMIPEXAZOLE - ANTIPARKINSONIAN DRUG

                                                                          PRAMIPEXOLE

MECHANISM OF ACTION –

 Pramipexole acts on dopaminergic receptors.

PHARMACOLOGICAL ACTION –

Improvement occurs in parkinsonian patients.

Postural hypotension

Inhibit prolactin release

USES –

1. Treating the signs and symptoms of Parkinson disease.

2. It is also used to treat restless legs syndrome (RLS).

SIDE EFFECTS -

Drowsiness

Hallucinations nausea

Trouble sleeping

Twitching, twisting, or other unusual body movements

Confusion

cough

difficulty with swallowing

double vision or other changes in vision

falling asleep without warning

fearfulness, suspiciousness, or other mental changes

fever

frequent urination

memory loss

muscle or joint pain

muscle weakness

restlessness or need to keep moving

swelling of the body

tightness in the chest

DRUG-DRUG INTERACTION –

Pramipexole + Propoxyphene = may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentration

REFERENCE: Tripathi K.D;'' Essentials of Medical Pharmacology'' ; Seventh Edition ; Page no. 425, 430-31