Miconazole
interacts
with 14-alpha demethylase, a cytochrome P450 enzyme necessary to convert
lanosterol to ergosterol. As ergosterol is an essential component of the fungal
cell membrane, inhibition of its synthesis results in increased cellular
permeability causing leakage of cellular contents. Miconazol may also inhibit
endogeneous respiration, interacts with membrane phospholipids, inhibit the
transformation of yeast to mycelia forms, inhibit purine uptake and impaired
triglyceride and phospholipid biosynthesis.
Reference:
Tripathi K.D;
Essentials of Clinical Pharmacology; Jaypee Brothers Medical Publishers;
Seventh edition; Page no. 787, 792
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