PIROXICAM
MECHANISM OF ACTION-
It involves inhibition of cyclooxygenase ( COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin synthesis in vitro.
USES-
1. Anti-inflammatory in rheumatoid
2. Acute gout
3. Musculoskeletal injuries
4. dentistry
SIDE EFFECTS-
1. Faecal blood loss
2. Rashes
3. Pruritus
4. Edema
PHARMACOLOGICAL ACTION-
It has analgesic, and antipyretic properties.
DRUG-DRUG INTERACTION-
Piroxicam + Aliskiren = decreases antihypertensive adtivity of aliskiren.
Piroxicam + Citric acid = increase anticoagulant activity.
Piroxicam + Diclofenac = increase risk of adverse effect.
REFERENCE : Tripathi K.D ; ''Essentials Of Medical Pharmacology' ;Seventh edition; Page no. 192,201-202,208,213
MECHANISM OF ACTION-
It involves inhibition of cyclooxygenase ( COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin synthesis in vitro.
USES-
1. Anti-inflammatory in rheumatoid
2. Acute gout
3. Musculoskeletal injuries
4. dentistry
SIDE EFFECTS-
1. Faecal blood loss
2. Rashes
3. Pruritus
4. Edema
PHARMACOLOGICAL ACTION-
It has analgesic, and antipyretic properties.
DRUG-DRUG INTERACTION-
Piroxicam + Aliskiren = decreases antihypertensive adtivity of aliskiren.
Piroxicam + Citric acid = increase anticoagulant activity.
Piroxicam + Diclofenac = increase risk of adverse effect.
REFERENCE : Tripathi K.D ; ''Essentials Of Medical Pharmacology' ;Seventh edition; Page no. 192,201-202,208,213
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