MECHANISM OF ACTION -
Pindolol non-selectively blocks ß-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure.
USES-
1. Antihypertensive
2. High blood pressure
3. Heart attack
4. Kidney problem
SIDE EFFECTS-
1. Chest pain
2. Heart attack
3. Irregular heartbeat
PHARMACOLOGICAL ACTION-
Pindolol is a nonselective ß blocker with partial ß adrenergic receptor agonist activity and also possesses intrinsic sympathomimetic activity.
It also shows membrane stabiling effects .
DRUG-DRUG INTERACTION-
Pindolol + Heptabarbital = decrease the serum concentration of ß-blockers
Pindolol + Amiodarone = may enhance the bradycardic effect of ß-blockers.
REFERENCE
Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.144
No comments:
Post a Comment