MERCAPTOPURINE
Description: An antimetabolite antineoplastic agent with immunosuppressant properties.
CLASS-PURINETHIONES
Uses: For remission induction and maintenance therapy of acute lymphatic leukemia.
Adverse Drug Reactions: Diarrhoea, loss of appetite, nausea, tiredness, vomiting
Drug-Drug Interactions:
Mercaptopurine + dicoumarol=decreased anticoagulant activity of dicoumarol
Mercaptopurine +allopurinol/ +febuxostat=serum concentration of mercaptopurine is increased
Mercaptopurine+azathioprine= increased myelosuppressive activities
Reference- Tripathi KD," Essentials of Medical Pharmacology",7th edition, page no- 216,858,863,874,882.
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