MOMETASONE - Topical Steroid

MECHANISM OF ACTION

Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. Inflammation is increased by diminishing the release of leukocytic acid hydrolyses , prevention of macrophage accumulation at inflamed sites , interference with leukocyte adhesion to the capillary wall, reduction of capillary membranes permeability , reduction of complement components, inhibitions of histamine and kinin release and interference with the formation of scar tissue.

DRUG DRUG INTERACTION

ALDESLEUKIN: Mometasone may decrease the anti neoplastic activity of aldesleukin.

ANPHOTERICIN B  : Mometasone may increase the hypokalemia activity of it.

CERITINIB : Mometasone may increase the hyperglycemic activity of it.

DEFERASIROX : the risk or severity of adverse effects can be increased when given with combo of mometasone.

CORTICORELIN OVINE TRIFLUTATE : the therapeutic activity of corticorelin may decreased when given with combo of Mometasone.

SIDE EFFECTS

• Body pain

• Cold or flu like symptoms

• Congestion

• Cough

• Sore throat

• Abdominal pain

• Loss of appetite

• Nausea

• Stuffy or runny nose

USES

• Anti-allergic agents

• Anti-inflammatory agents

• Dermatologic agents

• Glucocorticoids

• Nasal preparations

• Corticosteroids

• otologicals

REFERENCE

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.895.