Saturday, February 17, 2018

Memantine-Cognition enhancers


                                                                MEMANTINE

Description:
 It is an amantadine derivative with low to moderate-affinity for NMDA receptors. It is under investigation for the treatment of Alzheimer’s disease.
CLASS-CYCLOHEXYLAMINES

Uses:
 Treatment of moderate to severe dementia of the alzheimer’s type

Adverse Drug Reactions:
 Confusion, dizziness, insomnia, agitation, hypertonia, cystitis

Drug-Drug Interactions:
Memantine+bupropion/+lactic acid/+calcium acetate = serum concentration of memantine is increased
Memantine+acetazolamide=Decreased excretion rate of memantine
Reference- Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no-489,490

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