POSACONAZOLE SYSTEMIC MYCOSES ITS SIDE EFFECTS AND USES

MECHANISM OF ACTION- 
It inhibits fungal CYP450 enzyme lanosterol  14- demethylase and thus impairs ergosterol synthesis leading to a cascade of membrane abnormalities in the fungus.

USES-
1. To treat infections by Candida , Aspergillus , or fusarium species.

SIDE EFFECTS-
1. Nausea
2. Abdominal pain
3. Loose motion
4. Headache
5. Dizziness
6. drowsiness

PHARMACOLOGICAL ACTION-
It blocks the synthesis of ergosterol.
It is significantly more potent at inhibiting 14-a demethylase than itraconazole.

DRUG-DRUG INTERACTION-
Posaconazole + H2 blocker = reduce gastric acidity
Posaconazole + phenytoin = decreases metabolism
Posaconazole + PPI = reduce gastric acidity

REFERENCE

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.789