Pantoprazole-peptic ulcer drug and its pharmacology

Introduction

Pantoprazol  is a substituted benzimidazole indicated for the short-term treatment (up to 16 weeks) in the healing and symptomatic relief of erosive esophagitis.

 Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production.

THERAPEUTIC USES

-Pantoprazole is use to treat certain stomach and esophagus problem such as acid reflux.

-This relief symptoms such as heartburn, difficulty swallowing, and persistent cough.

-It helps heal acid damage to the stomach and esophagus.

-It help to prevent ulcers, and may help to prevent cancer of the esophagus.

Side effects

-Blurred vision

-Dry mouth

-Fruit like breath odor

-Increased urination

-Increased hunger and thrist

-Unexplained weight loss

Pharmacokinetics

Bioavailability                                  77%

Metabolism                                      Hepatic

Biological half-life                            1-2 hours

Excretion                                            Renal

Mechanism of action

Pantoprazole is a proton pump inhibitor (PPI) thatsuppresses the final in gastric acid  production by forming a covalent bond to two sites of the (H?,K?)-ATPase

enzyme system at the secretory surface of the gastric parietal cell. This effect is dose-related and lead to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.

 Drug-drug interaction

1-Pantoprazole+Amphetamine= It cause an increase in the absorption of     

                                                          Amphetamine resulting in an increased

                                                           Serum concentration.

2-Pantoprazole+Abiraterone= The metabolism of pantoprazole can be decreased.

3-Pantoprazole+Bortezomib= The metabolism of pantoprazole can be decreased

REFERENCE:

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no 387,649,653,657