Monday, February 19, 2018

Pantoprazole-peptic ulcer drug and its pharmacology

Pantoprazol  is a substituted benzimidazole indicated for the short-term treatment (up to 16 weeks) in the healing and symptomatic relief of erosive esophagitis.
 Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production.

-Pantoprazole is use to treat certain stomach and esophagus problem such as acid reflux.
-This relief symptoms such as heartburn, difficulty swallowing, and persistent cough.
-It helps heal acid damage to the stomach and esophagus.
-It help to prevent ulcers, and may help to prevent cancer of the esophagus.

Side effects
-Blurred vision
-Dry mouth
-Fruit like breath odor
-Increased urination
-Increased hunger and thrist
-Unexplained weight loss

Bioavailability                                  77%
Metabolism                                      Hepatic
Biological half-life                            1-2 hours
Excretion                                            Renal

Mechanism of action
Pantoprazole is a proton pump inhibitor (PPI) thatsuppresses the final in gastric acid  production by forming a covalent bond to two sites of the (H?,K?)-ATPase
enzyme system at the secretory surface of the gastric parietal cell. This effect is dose-related and lead to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.

 Drug-drug interaction
1-Pantoprazole+Amphetamine= It cause an increase in the absorption of     
                                                          Amphetamine resulting in an increased
                                                           Serum concentration.
2-Pantoprazole+Abiraterone= The metabolism of pantoprazole can be decreased.
3-Pantoprazole+Bortezomib= The metabolism of pantoprazole can be decreased

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no 387,649,653,657

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