MECHANISM OF ACTION –
Probencid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Probencid may also reduce plasma binding of urate and inhibit renal secretion of uric acid at subtherapeutic concentrations. The mechanism by which probencid inhibits renal tubular transport is known, but the drug may inhibit transport enzymes that require a source of high energy phosphate bonds and/or nonspecifically interefere with substrate access to peotein receptor sites on the kidney tubules.
PHARMACOLOGICAL ACTION –
1- The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate.
2- Probencid has also been used to treat patients with renal impairment , and , because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
USES –
1. Probencid is primarily used to treat gout amd hyperuricemia.
2. It is sometime used to increase the concentration of some antibiotics.
3. It has also found use as a masking agent .
SIDE EFFECTS –
1-Nausea, vomiting , headache.
2-Lower back pain
3- Painful urination , frequent urination
4-Loss of apetite
5-Dizziness
6-Sore gums
DRUG-DRUG INTERACTION –
1-Probencid + Aspirin = therapeutic efficacy of probencid can be decreased when used in combination with Aspirin.
2-Probencid + Amoxicillin = the serum concentration of Amoxicillin can be increased when it is combined with Probencid.
REFERENCE
Probencid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Probencid may also reduce plasma binding of urate and inhibit renal secretion of uric acid at subtherapeutic concentrations. The mechanism by which probencid inhibits renal tubular transport is known, but the drug may inhibit transport enzymes that require a source of high energy phosphate bonds and/or nonspecifically interefere with substrate access to peotein receptor sites on the kidney tubules.
PHARMACOLOGICAL ACTION –
1- The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate.
2- Probencid has also been used to treat patients with renal impairment , and , because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
USES –
1. Probencid is primarily used to treat gout amd hyperuricemia.
2. It is sometime used to increase the concentration of some antibiotics.
3. It has also found use as a masking agent .
SIDE EFFECTS –
1-Nausea, vomiting , headache.
2-Lower back pain
3- Painful urination , frequent urination
4-Loss of apetite
5-Dizziness
6-Sore gums
DRUG-DRUG INTERACTION –
1-Probencid + Aspirin = therapeutic efficacy of probencid can be decreased when used in combination with Aspirin.
2-Probencid + Amoxicillin = the serum concentration of Amoxicillin can be increased when it is combined with Probencid.
REFERENCE
Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.30
No comments:
Post a Comment