Phenazopyridine-Urinary analgesic and its pharmacology

Introduction

A local anesthetic that has been used in urinary tract disorders.Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.

Therapeutic Uses

-Relieving pain

-Burning

-Frequent urination

-Discomfort caused by irritation of the lower urinay tract

Side effects

-Blue or blue-purple color of skin

-Skin rashes 

-Weight gain

-Sudden decrease in the amount of urine

-Swelling of face, finger, feet, and/or lower legs

-Unusual tiredness or weakness

Mechanism of action

It is known that the chemical has a direct topical analgesic effect on the mucosa lining of the urinary tract.

Drug-drug interaction

1-Phenazopyridine+Dapsone= The risk of severity of adverse effects can be 

                                                      Increased when dapsone is combine with 

                                                      Phenazopyridine.

2-Phenazopyridine+Prilocaine= The risk of severity of adverse effects can be 

                                                       Increased when combine with phenazopyridine

REFERENCE:

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.761