Monday, February 19, 2018

Phenazopyridine-Urinary analgesic and its pharmacology

A local anesthetic that has been used in urinary tract disorders.Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.

Therapeutic Uses
-Relieving pain
-Frequent urination
-Discomfort caused by irritation of the lower urinay tract

Side effects
-Blue or blue-purple color of skin
-Skin rashes 
-Weight gain
-Sudden decrease in the amount of urine
-Swelling of face, finger, feet, and/or lower legs
-Unusual tiredness or weakness

Mechanism of action
It is known that the chemical has a direct topical analgesic effect on the mucosa lining of the urinary tract.

Drug-drug interaction
1-Phenazopyridine+Dapsone= The risk of severity of adverse effects can be 
                                                      Increased when dapsone is combine with 
2-Phenazopyridine+Prilocaine= The risk of severity of adverse effects can be 
                                                       Increased when combine with phenazopyridine


Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.761

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