MECHANISM OF ACTION-
It is a muscarinic receptor antagonist and binds to the muscarinic acetylcholine receptor. The Muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G protein.
USES-
1. Antisecretory action
2. Peptic ulcer
3. Antispasmodic
4. Bronchial asthama
5. Mydriatic
SIDE EFFECTS-
1. Dry mouth
2. Rashes
3. Fever
4. Photophobia
5. Blurred vision
PHARMACOLOGICAL ACTION-
It stimulates medullary centre.
It produces tachycardia.
Visceral smooth muscles are relaxed.
Decreases sweat , salivary or tracheobronchial secretion.
DRUG-DRUG INTERACTION-
Cimetidine + Pirenzipine = lowers gastric secretion.
REFERENCE
It is a muscarinic receptor antagonist and binds to the muscarinic acetylcholine receptor. The Muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G protein.
USES-
1. Antisecretory action
2. Peptic ulcer
3. Antispasmodic
4. Bronchial asthama
5. Mydriatic
SIDE EFFECTS-
1. Dry mouth
2. Rashes
3. Fever
4. Photophobia
5. Blurred vision
PHARMACOLOGICAL ACTION-
It stimulates medullary centre.
It produces tachycardia.
Visceral smooth muscles are relaxed.
Decreases sweat , salivary or tracheobronchial secretion.
DRUG-DRUG INTERACTION-
Cimetidine + Pirenzipine = lowers gastric secretion.
REFERENCE
Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.101
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