MEBENDAZOLE
MECHANISM OF ACTION-
The immobilizing and lethal action of mebendazole on worms is rather slow : take 2-3 days to develop. The site of action of mebendazole appears to be the microtubular protein ‘ß-tubulin’ of the parasite. It binds to ß-tubulin of susceptible worms with high affinity and inhibits its polymerization. Intracellular microtubules in the cells of the worm are gradually lost.
USES-
1. Broad-spectrum anthelmintic drug
2. Prolonged treatment has been shown to cause regression of hydatid cysts in the liver.
SIDE EFFECTS-
1. Diarrhoea
2. Nausea
3. Abdominal pain
4. Allergic reactions
5. Loss of hairs
PHARMACOLOGICAL ACTION-
It expels Trichinella spiralis from intestines, but efficacy in killing larvae that have migrated to muscles in uncertain.
DRUG-DRUG INTERACTION-
Mebendazole + Metronidazole = chances of Stevens- Johnson syndrome
Mebendazole +Sodium iodide-123 = affect the diagnostic results of sodium iodide i-123.
MECHANISM OF ACTION-
The immobilizing and lethal action of mebendazole on worms is rather slow : take 2-3 days to develop. The site of action of mebendazole appears to be the microtubular protein ‘ß-tubulin’ of the parasite. It binds to ß-tubulin of susceptible worms with high affinity and inhibits its polymerization. Intracellular microtubules in the cells of the worm are gradually lost.
USES-
1. Broad-spectrum anthelmintic drug
2. Prolonged treatment has been shown to cause regression of hydatid cysts in the liver.
SIDE EFFECTS-
1. Diarrhoea
2. Nausea
3. Abdominal pain
4. Allergic reactions
5. Loss of hairs
PHARMACOLOGICAL ACTION-
It expels Trichinella spiralis from intestines, but efficacy in killing larvae that have migrated to muscles in uncertain.
DRUG-DRUG INTERACTION-
Mebendazole + Metronidazole = chances of Stevens- Johnson syndrome
Mebendazole +Sodium iodide-123 = affect the diagnostic results of sodium iodide i-123.
Reference- Tripathi KD, " Essentials of Medical Pharmacology",7th edition, page no-849-50.
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