PRAMIPEXOLE BRAIN DOPAMINERGIC AGONIST ITS SIDE EFFECTS AND USES

MECHANISM OF ACTION –

Pramipexole acts on dopaminergic receptors.

PHARMACOLOGICAL ACTION –

1-Improvement occurs in parkinsonian patients.
2-Postural hypotension.
3-Inhibit prolactin release.

USES –

1. Treating the signs and symptoms of Parkinson disease.
2. It is also used to treat restless legs syndrome (RLS).

SIDE EFFECTS –

1- Drowsiness
2- Hallucinations nausea
3- Trouble sleeping
4- Twitching, twisting, or other unusual body movements
5- Confusion
6- cough
7- difficulty with swallowing
8- double vision or other changes in vision
9- falling asleep without warning
10- fearfulness, suspiciousness, or other mental changes
11- fever
12- frequent urination
13- memory loss
14- muscle or joint pain
15- muscle weakness
16- restlessness or need to keep moving
17- swelling of the body
18- tightness in the chest


DRUG-DRUG INTERACTION –

Pramipexole + Propoxyphene = may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating.

REFERENCE-

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.425