POSACONAZOLE
MECHANISM OF ACTION-
It inhibits fungal CYP450 enzyme lanosterol 14- demethylase and thus impairs ergosterol synthesis leading to a cascade of membrane abnormalities in the fungus.
USES-
1. To treat infections by Candida , Aspergillus , or fusarium species.
SIDE EFFECTS-
1. Nausea
2. Abdominal pain
3. Loose motion
4. Headache
5. Dizziness
6. drowsiness
PHARMACOLOGICAL ACTION-
It blocks the synthesis of ergosterol.
It is significantly more potent at inhibiting 14-a demethylase than itraconazole.
DRUG-DRUG INTERACTION-
Posaconazole + H2 blocker = reduce gastric acidity
Posaconazole + phenytoin = decreases metabolism
Posaconazole + PPI = reduce gastric acid Secretion
REFERENCE : Tripathi K.D ;'' Essentials of Medical Pharmacology'' ; Seventh Edition; Page no. - 789, 795
MECHANISM OF ACTION-
It inhibits fungal CYP450 enzyme lanosterol 14- demethylase and thus impairs ergosterol synthesis leading to a cascade of membrane abnormalities in the fungus.
USES-
1. To treat infections by Candida , Aspergillus , or fusarium species.
SIDE EFFECTS-
1. Nausea
2. Abdominal pain
3. Loose motion
4. Headache
5. Dizziness
6. drowsiness
PHARMACOLOGICAL ACTION-
It blocks the synthesis of ergosterol.
It is significantly more potent at inhibiting 14-a demethylase than itraconazole.
DRUG-DRUG INTERACTION-
Posaconazole + H2 blocker = reduce gastric acidity
Posaconazole + phenytoin = decreases metabolism
Posaconazole + PPI = reduce gastric acid Secretion
REFERENCE : Tripathi K.D ;'' Essentials of Medical Pharmacology'' ; Seventh Edition; Page no. - 789, 795
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