Paromomycin-aminoglycosides antibiotic and its pharmacology

         

Introduction

An oligosaccharide antibiotic, produced by various streptomyces.

Therapeutic Uses

-This medication is use to treat a certain parasite infection of the intestines (amebiasis).

-It may also be used along with a special diet to treat a certain serious brain problem (hepatic encephalopathy).

Side effects

-Nausea

- Vomiting

-Diarrhea

-Loss of appetite

-Ringing/roaring sound in the ear

-Change in the amount of urine

-Itching/swelling (especially of the face/tongue/throat)

-Severe dizziness

-Trouble breathing

Pharmacokinetics

Excretion            -       Fecal

Mechanism of action

Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. t-RNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.

REFERENCE:

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no 743,750,842,843,845,847