Monday, February 19, 2018

Paromomycin-aminoglycosides antibiotic and its pharmacology

An oligosaccharide antibiotic, produced by various streptomyces.

Therapeutic Uses
-This medication is use to treat a certain parasite infection of the intestines (amebiasis).
-It may also be used along with a special diet to treat a certain serious brain problem (hepatic encephalopathy).

Side effects

- Vomiting
-Loss of appetite
-Ringing/roaring sound in the ear
-Change in the amount of urine
-Itching/swelling (especially of the face/tongue/throat)
-Severe dizziness
-Trouble breathing

Excretion            -       Fecal

Mechanism of action

Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. t-RNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.


Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no 743,750,842,843,845,847

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