PINDOLOL
INTRODUCTION-
It has been used primarily as antihypertensive : may be advantages in patients who develop marked bardycardia with propanolol. chances rebound hypertension on withdrawal are also less.
MECHANISM OF ACTION-
Pindolol non-selectively blocks ß-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure.
USES-
1. Antihypertensive
2. High blood pressure
3. Heart attack
4. Kidney problem
SIDE EFFECTS-
1. Chest pain
2. Heart attack
3. Irregular heartbeat
PHARMACOLOGICAL ACTION-
Pindolol is a nonselective ß blocker with partial ß adrenergic receptor agonist activity and also possesses intrinsic sympathomimetic activity.
It also shows membrane stabiling effects .
DRUG-DRUG INTERACTION-
Pindolol + Heptabarbital = decrease the serum concentration of ß-blockers
Pindolol + Amiodarone = may enhance the bradycardic effect of ß-blockers.
REFERENCE-
ESSENTIAL OF MEDICAL PHARMACOLOGY BY K.D TRIPATHI 7th edition pg. no.-144,147
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