Mifepristone- Antiprogestin drug

MIFEPRISTONE

INTRODUCTION
A Progestational andglucocorticoid hormone antagonist.its inhibition of progesterone induces bleeding during the luteal phase in early pregnancy,by releasing endogenous prostaglandin from the endometrium or decidua.

PHARMACOKINETIC
Absolute bioavailability of 20 mg oral dose is 69%
Protein binding= 98%
Metabolism = Hepatic by cytochrome P450 3a4
Route of elimination = Faeca=83% and Renal =9%
Half life = 18 hours

USES
? Used to treat hyperscortsolism in patients with nonpituitary Cushing syndrome.
? Currently under investigation for use in psychotic depression (phase 3 trials)

SIDE EFFECTS
? Allergic reactions like hives
? Difficulty in breathing
? Swelling of your face, lips , tongue or throat

DRUG DRUG INTERACTIONS
? Mifepristone+Acenocoumarol      =  Serum concentration of Acenocoumarol increases
? Mifepristone+Acetohexamide      =  Hypoglycemic activity of Mifepristone increases
? Mifepristone+Acetylsalicylic acid =  Hyooglycemic activity of Mifepristone increases
? Mifepristone+Alfentani                 =  Serum concentration of Alfentanil increases
? Mifepritone+Alfuzosin                  =  Serum concentration of Alfuzosin increases

Reference-Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no-319,320,323