INTRODUCTION-
Pheniramine is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment of allergic conjunctivitis.
Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. As an example, Neo Citran contains pheniramine.
USES-
1-Used to temporarily relieve symptoms caused by the common cold, flu, allergies, or other breathing illnesses (such as sinusitis, bronchitis).
2-It help to relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.
SIDE EFFECTS-
1- Drowsiness or bradycardia,
2-Over-dosage may lead to sleep disorders
3- Seizures
4-Loss of consciousness.
MECHANISM OF ACTION-
Antihistamines such as pheniramine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for H1-receptors.
DRUG DRUG INTERACTION-
1-Acebutolol
The risk or severity of adverse effects can be increased when Acebutolol is combined with 2-Pheniramine.
2-Alfuzosin
Alfuzosin may decrease the vasoconstricting activities of Pheniramine.
3-Amitriptyline
Amitriptyline may increase the activities of Pheniramine.
4-Amphetamine
The risk or severity of adverse effects can be increased when Amphetamine is combined with Pheniramine.
5-Benzphetamine
The risk or severity of adverse effects can be increased when Benzphetamine is combined with 6-6-Pheniramine.
6-Cabergoline
Cabergoline may increase the hypertensive activities of Pheniramine.
7-Chlorphentermine
The risk or severity of adverse effects can be increased when Chlorphentermine is combined with Pheniramine.
.
8-Dobutamine
The risk or severity of adverse effects can be increased when Dobutamine is combined with Pheniramine.
9-Dopamine
The risk or severity of adverse effects can be increased when Dopamine is combined with Pheniramine.
REFERENCE-
Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.164
Pheniramine is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment of allergic conjunctivitis.
Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. As an example, Neo Citran contains pheniramine.
USES-
1-Used to temporarily relieve symptoms caused by the common cold, flu, allergies, or other breathing illnesses (such as sinusitis, bronchitis).
2-It help to relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.
SIDE EFFECTS-
1- Drowsiness or bradycardia,
2-Over-dosage may lead to sleep disorders
3- Seizures
4-Loss of consciousness.
MECHANISM OF ACTION-
Antihistamines such as pheniramine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for H1-receptors.
DRUG DRUG INTERACTION-
1-Acebutolol
The risk or severity of adverse effects can be increased when Acebutolol is combined with 2-Pheniramine.
2-Alfuzosin
Alfuzosin may decrease the vasoconstricting activities of Pheniramine.
3-Amitriptyline
Amitriptyline may increase the activities of Pheniramine.
4-Amphetamine
The risk or severity of adverse effects can be increased when Amphetamine is combined with Pheniramine.
5-Benzphetamine
The risk or severity of adverse effects can be increased when Benzphetamine is combined with 6-6-Pheniramine.
6-Cabergoline
Cabergoline may increase the hypertensive activities of Pheniramine.
7-Chlorphentermine
The risk or severity of adverse effects can be increased when Chlorphentermine is combined with Pheniramine.
.
8-Dobutamine
The risk or severity of adverse effects can be increased when Dobutamine is combined with Pheniramine.
9-Dopamine
The risk or severity of adverse effects can be increased when Dopamine is combined with Pheniramine.
REFERENCE-
Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.164
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