PIOGLITAZONE-ORAL HYPOGLYCEMICS DRUG

                                                                                                                                                                                                                                  PIOGLITAZONE

MECHANISM OF ACTION-
 It tends reverse insulin resistance by enhancing GLUT4 expression and translocation.

USES-
1. Oral anti-daiabetic
2. Lowers serum triglyceraldehyde level
3. Increases HDL
SIDE EFFECTS-
1. Plasma vo
 lume expansion
2. Edema
3. Weight gain
4. Headache
5. Mild anaemia

PHARMACOLOGICAL ACTION-
It reduces blood glucose and HbA1c without increasing circulating insulin.
It is used as a supplement to SUD/Metformin.

DRUG-DRUG INTERACTION-
Pioglitazone + Rifampin = induce metabolism of pioglitazone
Pioglitazone + Ketoconazole = inhibit metabolism of pioglitazone

Reference-Tripathi KD," Essentials of Medical Pharmacology", 7th edition, page no-270,272,276-277,279,280