PIROXICAM NON- SELECTIVE COX INHIBITOR ITS SIDE EFFECTS AND USES

MECHANISM OF ACTION-
 It involves inhibition of cyclooxygenase ( COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin synthesis in vitro.

USES-
1. Anti-inflammatory in rheumatoid
2. Acute gout
3. Musculoskeletal injuries
4. dentistry

SIDE EFFECTS-
1. Faecal blood loss
2. Rashes
3. Pruritus
4. Edema

PHARMACOLOGICAL  ACTION-
It has analgesic, and antipyretic properties.

DRUG-DRUG INTERACTION-
Piroxicam + Aliskiren = decreases antihypertensive adtivity of aliskiren.
Piroxicam + Citric acid = increase anticoagulant activity.
Piroxicam + Diclofenac = increase risk of adverse effect.

REFERENCE

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no192