MECHANISM OF ACTION
Mirtazpine acts as an antagonist at central presynpatic alpha2 receptors, inhibiting negative feedback to the presynaptic nerve and causing and increase in NE release. Blockade of hetroreceptors alpha2 receptors contained in serotenergic neurons, enhances the release of 5HT – increasing the interaction between 5HT AND 5HT1 receptors and contributing to the anxiolytic effects of Mirtazpine.
USES
1. Atypical antidepressant
2. Anxiolytic
3. Hypnotic
4. Antiemetic
5. Appetite stimulant
6. Insomnia
7. Itching
8. Headache and migraine
9. Panic disorder
10. Post traumatic stress disorder
SIDE EFFECTS
1. Constipation
2. Dry mouth
3. Sedation
4. Weakness
5. Weight gain
6. Peripheral edema
DRUG DRUG INTERACTION
1. Mirtazapine + apraclonidine = Mirtazpine may decrease the antihypertensive activities of apraclonidine
2. Mirtazapine + aprepitant = the serum concentration of Mirtazpine can be increased when given with combination
3. Mirtazapine + alprazolam = alprazolam may increase the CNS depressant activity of mirtazapine
4. Mirtazapine+ alfentanil = alfentanil may increase CNS depressant of mirtazapine.
5. Mirtazapine + abiraterone = the serum concentration of mirtazapine can be increased.
REFERENCE
Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no-454,548,462.
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