Metyrapone blocks cortisol synthesis by
reversibly inhibiting steroid-11 beta hydroxylase. This stimulates
ACTH secretion, which in turn increases plasma 11-deoxycortisol levels. It is an
adrenal steroid synthesis inhibitor.
Reference:
Tripathi K.D;
Essentials of Clinical Pharmacology; Jaypee Brothers Medical Publishers;
Seventh edition; Page no. 295
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