Sunday, April 8, 2018


Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid-11 beta hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-deoxycortisol levels. It is an adrenal steroid synthesis inhibitor.

Reference: Tripathi K.D; Essentials of Clinical Pharmacology; Jaypee Brothers Medical Publishers; Seventh edition; Page no. 295


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