Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968.
-Retention of urine
-Granular deposits in cornea
Mechanism of action
Penfluridol blocks the postsynaptic dopamine receptor in the mesolimbic dopaminergic system and inhibits the release of hypothalamic and hypophyseal hormones.
1-Penfluridol+MAOIs= Orthostatic hypotension
2-Penfluridol+Metoclopramide= May increase risk of extrapyrimidal symptom
3-Penfluridol+Amphetamine= May increase psychosis
4-Penfluridol+Levodopa= May inhibit antiparkinsonian effect