PIRENZEPINE - DRUG ACTING ON ANS

                                                         PIRENZEPINE
                                                                                              
MECHANISM OF ACTION- 
It is a muscarinic receptor antagonist and binds to the muscarinic acetylcholine receptor. The Muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G protein.

USES- 
1. Antisecretory action
2. Peptic ulcer
3. Antispasmodic
4. Bronchial asthama
5. Mydriatic

SIDE EFFECTS-
1. Dry mouth
2. Rashes
3. Fever
4. Photophobia
5. Blurred vision

PHARMACOLOGICAL  ACTION-
It stimulates medullary centre.
It produces tachycardia.
Visceral smooth muscles are relaxed.
Decreases sweat , salivary or tracheobronchial secretion.

DRUG-DRUG INTERACTION- 
Cimetidine + Pirenzipine = lowers gastric secretion

REFERENCE : Tripathi KD ;Essentials of medical pharmacology; seventh edition; page no. 101,115,117,654