Lynestrenol- 19 nor-testosterone derivative drug

LYNESTRENOL

MECHANISM OF ACTION – 

 As a synthetic oral progestogen, Lynestrenol has similar effects as that of the natural progesterone hormone. It has a strong progestational effect on the uterine endometrium by transforming the proliferative endometrium into a secretory one. It also inhibits the secretion of gonadotropin, suppresses maturation of follicles in the ovaries and ovulation, and reduces menstrual bleeding. Lynestrenol has minimal estrogenic, androgenic and anabolic effects.

PHARMACOLOGICAL ACTION – 

It converts watery cervical secretion to viscid secretion.

Induces pregnancy like changes in vaginal mucosa.

Proliferation of acini in the mammary glands.

It has a sedative effect.

0.5 0C rise in body temperature.

Exerts negative feedback at the level of hypothalamus.

USES – 

1. Contraceptive 

2. Hormone replacement therapy 

3. Premenstrual tension 

4. Habitual abortion 

5. Endometrial carcinoma 

SIDE EFFECTS –

Anaphylaxis or Anaphylactoid reactions.

Acne 

Blood sugar level increases

Amenorrhoea 

Edema

Rashes

Urticaria

Atheriosclerosis

Mental depression

Breast tenderness

Pain

DRUG-DRUG INTERACTION –

Lynestrenol + activated charcoal = leading to irregular bleeding .

Lynestrol + Carbamazepine = increased metabolism and reduced effectiveness of the drug.

Lynestrol + Phenytoin = increased metabolism and reduced effectiveness of the drug. 

Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 316 318