Metyrapone- Corticosteroidal drug

METYRAPONE

INTRODUCTION
It is an inhibitor of the enzyme steroid 11 beta monooxygenase. It is used as a test of the feedback hypothalamic pituitary mechanisms in the diagnosis of Cushing syndrome.

PHARMACOKINETIC
Absorption   = Rapidly and well absorbed orally
Metabolism = Hepatic , Conjugation with glucuronide

USE
? It is used to test if pituitary is sending proper signals to your adrenal glands.

SIDE EFFECTS
? Dizziness, nausea, vomiting, drowsiness, headache, stomach pain, allergic reactions

DRUG DRUG INTERACTIONS
? Metyrapone+Acetaminophen =         serum concentration of Acetaminophen increases
? Metyrapone+Aripiprazole         =        serum concentration decreases of Aripiprazole
? Metyrapone+Phosphenytoin   =         serum concentration of Metyrapone decreases
? Metyrapone+Hydrocodone      =         serum concentration of hydrocodone decreases
? Metyrapone=Phenytoin            =          serum concentration of Metyrapone decrease

Reference-Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no-295