Midazolam- General anasthetic

MIDAZOLAM

INTRODUCTION
A short acting hypnotic-sedative drug with  anxiolytic and amnestic properties.

PHARMACOKINETICS-
Absorption-rapidly absorbed after  oral administration.
Absolute bioavailability if i.m. >90%
Cmax,IM =90ng/ml
TMAX,IM=0.5 HRS

USES
? Used in dentistry
? Used in cardiac surgery
? Endoscopic procedures,as pre-anaesthetic medication
? As an adjunct to local anaesthethic

SIDE-EFFECTS
? Drowsiness, sedation
? Amnesia or short term memory loss
? Breathing difficulties
? Restlessness
? Agitation
? Disorientation

DRUG –DRUG INTERACTIONS
MIDAZOLAM+AMODIAQUINE=serum concentration of aodiaquine can be increased’
MIDAZOLAM+APREPITANT=serum concentration of midazolam can be increased.
MIDAZOLAM+ATAZANAVIR=serum concentration of midazolam can be increased.
MIDAZOLAM+AZELASTINE=CNS depressant activitiesof azelastine is increased.
MIDAZOLAM+BACLOFEN=risk of severity of adverse effects can be increased.

Reference-Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no-378,383