Introduction
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
THERAPEUTIC USES
Given by intramuscular injection to treat gonorrhea, in patient allergic to penicillins.
SIDE EFFECT
- Itching
- Chills
- Stomach ache
- Red rashes
MECHANISM OF ACTION
It is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30s ribosomal subunit. It is bactericidal in its action.
DRUG-DRUG INTERACTION
Spectinomycin+Avibactam= It may increase the Nephrotoxic activities of
Spectinomycin.
Spectinomycin+Alendronate= It may increase the activities of alendronate.
Spectinomycin+Bumetanide= The risk or severity of adverse effects can be Increased when bumetanide is combined with Spectinomycin.
Spectinomycin+Carboplatin=It may increase the Ototoxic activity of carboplatin
REFERENCE
Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no.758
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