Mitoxantrone - Anti-cancer Drug

MECHANISM OF ACTION

Mitoxantrone, a DNA-reactive agent that intercalates into DNA through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with RNA and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damage DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells,suggesting lack of cell cycle phase specificity.

USE

1. Antineoplastic agents

2. Immunosuppressive agents

3. Analgesics

4. CYP2E1 Inhibitor

5. CYP3A4 inhibitor

6. Anthracycline and related substance

SIDE EFFECTS

1. Vomiting

2. Adema

3. Weight gain

4. Fatigue

5. Decreased haemoglobin

6. Anorexia

7. Epigastric pain

8. Fever and dyspepsia

9. Renal failure

10. Pneumonia

11. Ischemic heart disease

DRUG DRUG INTERACTION

1. DENOSUMAB + MITOXANTRONE: The risk or severity of adverse effect can be increased

2. DIGOXIN + MITOXANTRONE: Digoxin may decrease the cardiotoxic activities

3. DOCETAXEL + MITOXANTRONE: The risk or severity of adverse effect can be increased

4. CLOZAPINE + MITOXANTRONE: The risk or severity of adverse effect can be increased

5. CYCLOPHOSFOMIDE + MITOXANTRONE: cyclophofomide may decrease the cardiotoxic activities

REFERENCE

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no. 858,867,868.