Lorazepam
Mechanism of action
It binds to an allostaeric site on GABA –A receptor which inhibits GABA and further opens chloride channel in receptor causing hyper-polarization of the neuron.
Therapeutic uses
In treatment of anxiety , seizures
Sedation
Agitation
Side effect
Low blood pressure
Confusion
Ataxia
Sedation , dizziness, weakness
Pharmacological action
It is a benzodiazepine medication.used in treatment of anxiety,trouble sleeping,status epileptics ,alcohol withdrawal. It can be given orally or as an injection into muscle or vein.
Drug drug interactions
Lorazepam+alprazolam = risk of severe adverse effects increases
Lorazepam+valproate = valproate decreases metabolism of lorazepam
Lorazepam+carbamazipine = increase rate of metabolism
Lorazepam+phenytoin = increase rate of metabolism
Lorazepam+ rifampin= increase rate of metabolism
Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 383,398,419,424,466
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