Methenamine
DESCRIPTION:
Hexamethylenetetramine or methenamine is a heterocyclic
organic compound with the formula (CH2)6N4. This white crystallinecompound is highly soluble in water and polar
organic solvents. It has a cage-like structure similar to adamantane. It is useful in the synthesis of other
chemical compounds, e.g., plastics, pharmaceuticals, rubber additives. It sublimes in vacuum at 280 °C
Medical uses
As the mandelic acid salt (generic
methenaminemandelate, USP[8]) it is used for the treatment of urinary
tract infection. It decomposes at an acidic pH to form formaldehyde and ammonia, and the formaldehyde is bactericidal; the
mandelic acid adds to this effect. Urinary acidity is typically ensured by
co-administering vitamin C (ascorbic
acid) or ammonium
chloride. Its use had
temporarily been reduced in the late 1990s, due to adverse effects,
particularly chemically-induced hemorrhagic cystitis in overdose,[9]
Interactions
See also How to Use section.
The effects of some drugs can change if you
take other drugs or herbal products at the same time. This can increase your
risk for serious side effects or may cause your medications not to work
correctly. These drug
interactions are possible,
but do not always occur. Your doctor or pharmacist can often prevent or manage
interactions by changing how you use your medications or by close monitoring.
Side Effects
Nausea, vomiting, diarrhea, abdominal cramps, and loss of appetite may occur. If any of
these effects persist or worsen, tell your doctor or pharmacist promptly.
Painful or difficult urination may occur with
methenamine, although less often. Report these side effects to your doctor, who
may need to lower your dose of methenamine or change your treatment to make
your urine less acidic.
REFERANCE- Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no-760,762
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