Fluticasone Propionate- Drug for cough and bronchial asthama and its Drug Drug Interactions

MECHANISM OF ACTION:

Binds to glucocorticoid receptor .Unbound corticosteroids can crodd the membrane of cells of such as mast cells and eosinophils ,binding with high affinity to glucocorticoid receptor .

The results include alteration of transription and protein synthesis , a decreased synthesis of hydrolases ,reduction in fibroblast proliferation. The glucorticoid receptor down regulates 

down regulates proinflammatroy regulators as interleukins.

THERAPEUTIC USES:

A medium potency synthetic corticosteroid ,it is used topically to relieve inflammatory and pruritic symptoms of dermatosis and psoriaisis ,intranasally to manage symptoms

of allergic and non allergic rhinitis.

SIDE EFFECTS:

The dose swallowed after inhalation has lo propensity to cause systemic side effects .

DRUG DRUG INTERACTION

1.Amphetamine + Fluticasone propionate = May decrease the sedative activity of fluticasone.

2. Amitryptyline + Fluticasone propionate = The risk or severity of side effects may be increased.

3. Baclofen + Fluticasone propionate = Increase the CNS activity  of fluticasone.

REFERENCE- Tripathi K D"Essential of medical pharmacology",7th edition ,page no- 231.