Flutamide- Androgen and drug for erectile dysfunction and its side effects.

PHARMACOLOGICAL ACTION :

It is a non steroidal antiandrogen . It exerts its antiandrogenic action by inhibiting androgen uptake or by inhibiting nuclear binding of androgen in target tissues or both.

MECHANISM OF ACTION :

It is a non steroidal anti androgen that blocks the action of exogenous and endogenous testosterone by binding to the androgen receptor . In addition it is a potent inhibitor 

of testosterone stimulated prostatic DNA synthesis.

SIDE EFFECTS :

• It has hepatotoxic potential.
• Causes breast tenderness and gynaecomastia .

DRUG DRUG INTERACTION:

1. Flutamide + abiraterone =serum concentration may be increased.

2. Flutamide +bortizomib= metabolism of flutamide can be decreased.

THERAPEUTIC USES:

For the management of locally confined stage B2 –C and stage D2 metastatic carcinoma of prostate.

REFERENCE-  Tripathi K D"Essential of medical pharmacology",7th edition ,page no- 302, 858.