Flurazepam- Sedative- Hypnotics and its side effects.

MECHANISM OF ACTION :

It binds to an allosteric site on GABA-A receptors.Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel 

with the receptor causing chloride influx and hyperpolarization.

THERAPEUTIC USES:

• For short term and intermittent use in patients with recurring insomnia and poor sleeping habits.
• Anti anxiety agent 
• Sedative.

SIDE EFFECTS 

• Coma  
• Confusion 
• Low blood pressure 
• Sleepiness

DRUG DRUG INTERACTIONS:

1. Azelastine + Flurazepam = serum concentration can be increased.
2. Clozapine + Flurazepam = risk of severity and adverse effects can be increased.
3. Baclofen + Flurazepam = risk and severity of adverse effects can be increased.

REFERENCE- Tripathi K D"Essential of medical pharmacology",7th edition ,page no- 404, 405