Flupenthixol:- antipsychotic and antimanic drug and its side effects

MECHANISM OF ACTION:
Its antipsychotic effects are caused by D2 and or 5HT-2 antagonism ,whereas its antidepressant effects at lower doses may be mediated by prefrential d2/d3 

autoreceptor blocakde ,resulting in increased post synaptic activation.

PHARMACOLOGICAL ACTIONS:

 1. CNS

In a normal individual  CPZ produces indifference to surroundings ,paucity of thought .

In psychotic individual , reduces irrational behaviour ,agitaton,and controls psychotic symptomatology.

2. LOCAL ANAESTHETIC

It is not used for this purpose because of its irritant action.

3.CVS

Neuroleptics produce hypotension by a central as well as peripheral action.

SIDE EFFECTS:

• Muscle rigidity 
• Hypokinesia 
• Hyperkinesia
• Parkinsonism
• Tremor

REFERENCE:- Tripathi K D"Essential of medical pharmacology",7th edition ,page no-440,441