Fluoxetine:- Antidepressant and Antianxiety drug and its drug -drug interaction

                                                           

PHARMACOLOGICAL ACTION:
It is an anti depressant agent belonging to SSRI. A functional decrease in activity of amines , such as serotonin and norepinephrine ,would result in depression ,

a functional increase in the activity would mood elevation.

MECHANISM OF ACTION:
It is a selective serotonin reuptake inhibitor . It inhibits the reuptake of serotonin at the serotonin reuptake pump of neuronal membrane ,enhancing the action of serotonin 

on 5HT 1A autoreceptors.

SIDE EFFECTS :

• Agitation, hypomania , and other signs of CNS  excitation.
• Anxiety ,nervousness ,insomnia 
• Anorexia , nausea diarrhea vasodilation dry mouth.

THERAPEUTIC USES:

In major depressive disorder ,moderate to severe bulimia ,obsessive compulsive disorder ,panic disorder.

DRUG DRUG INTERACTION

1. Fluoxetine + Abciximab = Increase the anticoagulant activities of Abciximab

2. Fluoxetine + Alteplase = Increase the anticoagulant activities of Alteplase

3. Fluoxetine + Amoxapine = Risk of adverse effects increases

REFERENCE:-Tripathi K D"Essential of medical pharmacology",7th edition ,page no-458,461