MECHANISM OF ACTION:
It is a non selective calcium antagonist with moderate other actions like anti-histaminic, dopamine and serotonin receptor blocker
It antagonises the calmodilin, calcium binding protein and blocks the calcium channels.
THERAPEUTIC USES;
- Effective in prophylaxis of migraine
- Occlusive in peripheral vascular disease
- Vertigo of central and peripheral regions
- Adjuvant therapy in epilepsy
SIDE EFFECTS:
- Drowsiness
- Weight gain
- Depression
- Extra pyramidal effects
- DRUG DRUG INTERACTIONS:
- Flunarizine+ anti hypertensive =effect of anti hypertensive can be increased
- Flunarizine+alcohol=effect of alcohol increases
CONTRAINDICATIONS
- Contraindicated in the patient with depression
- Contraindicated in the patient who have Parkinson disease
- Contraindicated in patient with acute phase of stroke.
REFERENCE- Tripathi K D"Essential of medical pharmacology",7th edition ,page no-180
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