Ethionamide-antitubercular drug and its pharmacology

MECHANISM OF ACTION

Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organism. It is a nicotinic acid derivative. It undergoes intracellular modification and acts similar to isonazid. Isonazide inhibits the syntonent of the bacterial cell wall.hesis of mucoloic acids.

DRUG DRUG INTERACTION

• CYCLOSERINE: The risk or severity of adverse effect can be increased when Ethionamide is combined with Cycloserine.

• ETHANOL: : The risk or severity of adverse effect can be increased when Ethionamide is combined with ethanol.

SIDE EFFECTS

Common Side Effect

• Dizziness

• General Body Discomfort

• Headache

• Nausea

• Stomach Upset Or Pain

• Vomiting

Severe Side Effect

• Rash

• Hives

• Itching

• Difficulty in Breathing

• Pain in chest or tightness

• Confusion

• Dark urine

• Fever

• Joint pain

• Swelling or sever Tenderness

• Persistent loss of appetite

• Swollen gland in the neck or armpit

THERAPEUTIC USES

• Treating Tuberculosis infection in combination with other medicines

• It is an antibacterial agent

• It inhibits or stops the growth of TB cell

REFERENCE:-Tripathi K D"Essential of medical pharmacology",7th edition ,page no-765,766,771,776,782